The primary goal of János Szabadics’ laboratory is to better understand the underlying neuronal circuitry of the hippocampus, in particular the cellular machinery of the interface between the dentate gyrus and CA3 regions. The central methodology of the laboratory is the in vitro patch clamp electrophysiology (including paired recordings of synaptically coupled neurons, and direct dendritic and axonal recordings), which is combined with correlated anatomy and immuno-histochemistry, calcium-imaging, computational modelling and virus labelling. Combination of these methods allow us to investigate how inputs are translated and processed into neuronal output at the level of individual neurons and what are the fundamental mechanisms of synaptic communications between individual neurons. The laboratory started its operation in July 2009 and the ongoing projects are funded by the Wellcome Trust, by the “Lendulet” Young Investigator Program from the Hungarian Academy of Sciences and by the Hungarian Brain Research Program.
Please see also: http://www.koki.hu/main.php?folderID=986
Brunner J, Neubrandt M, Van-Weert S, Andrási T, Kleine Borgmann FB, Jessberger S, Szabadics J (2014). Adult-born granule cells mature through two functionally distinct states. eLife, 3: e03104
Brunner J., Ster J., Van-Weert S., Andrási T., Neubrandt M., Corti C., Corsi M., Ferraguti F., Gerber U., Szabadics J. (2013) Selective silencing of individual dendritic branches by an mGlu2-activated potassium conductance in dentate gyrus granule cells. J. Neurosci., 33 (17) : 7285-98.
Beyeler A., Retailleau A., Molter C., Mehidi A., Szabadics J., Leinekugel X. (2013) Recruitment of perisomatic inhibition during spontaneous hippocampal Activity. PLoS One, 8 (6) : e66509.
Lee SY., Foldy C., Szabadics J., Soltesz I. (2011) Cell-type-specific CCK2 receptor signaling underlies the cholecystokinin-mediated selective excitation of hippocampal parvalbumin-positive fast-spiking basket cells. J. Neurosci., 31 (30) : 10993-11002.
Szabadics J., Varga C., Brunner J., Chen K., Soltesz I. (2010) Granule cells in the CA3 area. J. Neurosci., 30(24) : 8296-8307.