|Cv||CV June 2014||almost 3 years ago|
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Our research is based in the consideration of biological images as complex systems. We combine computerized image analysis and network science to extract the defining signature of complex images and interpret biological processes in development and disease. Consequently, our ongoing research has diversified into different projects: from the topological analysis of fly morphogenesis to the investigation of human neuromuscular disorders.
Network analysis of muscle organization. The diagnosis of neuromuscular diseases is strongly based on the histological characterization of muscle biopsies. However, this morphological analysis is mostly a subjective process and difficult to quantify. We have developed NDICIA, a new method that extract useful information from muscle samples in an objective, automated, fast and precise manner. NDICIA quantification of the severity of muscular dystrophies strongly correlates with the evaluation of the degree of affectation carried out by the pathologist, confirming the method as a useful diagnostic tool.
Continuing the study of muscle biopsies, we are applying our diagnostic tool to the investigation of more neuromuscular diseases. We have also adapted the method for the analysis of mice biopsies. We are now following the postnatal development of mouse muscles to later extent the analysis to different neuromuscular disease models.
For further information, please also see: http://www.ibis-sevilla.es/investigacion/neurociencias/mecanismos-de-mantenimiento-neuronal/escudero-cuadrado-luis-maria.aspx?lang=en-US
Sáez A., Acha B., Montero-Sánchez A., Rivas E., Acha B., Escudero LM., Serrano C. (2013) A neuromuscular disease classification system. J. Biomed. Opt. , 18 (6) : 66017.
Sáez A., Rivas E., Montero-Sánchez A., Paradas C., Acha B., Pascual A., Serrano C., Escudero LM. (2013) Quantifiable diagnosis of muscular dystrophies and neurogenic atrophies through network analysis. BMC Med ., 11 : 77.
Aldaz S., Escudero LM., Freeman M. (2013). Dual role of myosin II duringDrosophila imaginal disc metamorphosis. Nat. Commun ., 4: 1761.
Escudero LM., Costa LdaF., Kicheva A., Briscoe J., Freeman M., Babu MM.(2011). Epithelial organisation revealed by a network of cellular contacts. Nat. Commun ., 2: 526.
Aldaz S., Escudero, LM., Freeman M. (2010). Live imaging ofDrosophila imaginal disc development. Proc. Natl. Acad. Sci. U S A , 107 (32) : 14217-22.
2014 PI, Clinical & Pre-Clinical Investigation of Neuromuscular Diseases Through Computerized Image Analysis, ISCIII
2013 Ramón y Cajal Contract
2011 PI, Drosophila Genetics and Computerized Image Analysis for the Study of Neurological Diseases
2005 Postdoctoral Marie Curie Fellowship
2005 EMBO Postdoctoral Fellowship
2010 Miguel Servet Contract, Spanish Ministry of Health
2010 PI, Search & Selection of Parkinson´s Disease Candidate Genes and Validation by Human Genetic Analysis, ISCIII
1999 Predoctoral Comunidad Autónoma de Madrid Fellowship
1997 Undergraduate Fellowship, Spanish Ministry of Science