Dr. Erik Keimpema Medical University of Vienna – The European Neuroscience Institute - Medical University of Vienna

Molecular Neurosciences

Medical University of Vienna
[email protected]
+43 1 40160-34062
Austria

Documents

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About Dr. Erik Keimpema

My research interests encompass describing the molecular machinery underlying the signals important for the proper development of the fetal brain. These include endocannabinoids, which are lipid signals promoting neurite outgrowth and growth cone motility, both in cortical pyramidal cells and basal forebrain cholinergic neurons (Keimpema, 2010-J Neurosci; Keimpema, 2013-PNAS). We also showed that endocannabinoid signaling can mediate chemorepulsion by regulating Robo/Slit signaling in cortical pathfinding (Alpar, 2014-Nat Commun). Our studies on the molecular organization of endocannabinoid signaling eventually led to the description of a model of cannabis sensitivity in the developing fetal brain (Keimpema et al., 2011-TiPS).

My interests in fetal development led me to describe the role of neuropeptides, such as galanin, in the development of cholinergic neurons (Keimpema, 2013-Cereb Cortex). Furthermore, in a study concerning endocannabinoid signaling in the pancreas (Malenczyk et al., 2013-J Biol Chem), we demonstrated that endocannabinoids control insulin release by reorganizing the actin cytoskeleton.

For further information, please also see: http://cbr.meduniwien.ac.at/people/persons-details/id/311

Publications
Keimpema E, Mulder J, Aguado T, Barabás K, Ballester Rosado CJ, Nguyen L, Monory K, Marsicano G, Di Marzo V, Hurd YL, Guillemot F, Mackie K, Lutz B, Guzmán M, Lu HC, Galve-Roperh I, Harkany T. (2008) Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning Proc Natl Acad Sci U S A, 105:, Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning, 8760-8765. PDF (3 MB)
Keimpema E, Barabás K, Morozov YM, Tortoriello G, Torii M, Cameron G, Yanagawa Y, Watanabe M, Mackie K, Harkany T. (2010) Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding J Neurosci.,, 30:, Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding, 13992-4007. PDF (7.54 MB)
Keimpema E, Tortoriello G, Alpar A, Capsoni S, Arisi I, Cattaneo A, Doherty P, Mackie K, Harkany T. (2013) Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons Proc Natl Acad Sci U S A., 110, Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons, 1935-40. PDF (1.82 MB)
Keimpema E, Zheng K, Barde S, Berghuis P, Dobszay MB, Schnell R, Mulder J, Luiten PGM, Xu ZD, Runesson J, Langel Ü, Lu B, Hökfelt T, Harkany T. (2013) Neonatal γ-aminobutyric acidergic terminals are a source of galanin to orchestrate cholinergic neuron development Cerebral Cortex, Epub., Neonatal γ-aminobutyric acidergic terminals are a source of galanin to orchestrate cholinergic neuron development
Keimpema E, Mackie K, Harkany T. (2011) Molecular model of cannabis sensitivity in developing neuronal circuits Trends Pharmacol Sci., 32:, Molecular model of cannabis sensitivity in developing neuronal circuits, 551-61. PDF (1.04 MB)