About Dr. Romain Goutagny

How the brain integrate and store information and how this process is affected in pathological states remain poorly understood. This is mainly due to the fact that a multidisciplinary approach is required to tackle this question across its different levels of complexity. In our group we combine in vivo multi-site electrophysiological recording with behavioral testing in various animal models in order to find neuronal correlates of memory acquisition and retrieval and to determine how these processes are affected in neuropsychiatric disorders such as Alzheimer’s disease and depression.

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5 Selected Publications

Hamm V, Héraud C, Bott JB, Herbeaux K, Strittmatter C, Mathis C, Goutagny R. Differential contribution of APP metabolites to early cognitive deficits in a TgCRND8 mouse model of Alzheimer's disease. Sci Adv. 2017 Feb 24;3(2):e1601068.

Bott JB, Héraud C, Cosquer B, Herbeaux K, Aubert J, Sartori M, Goutagny R*, Mathis C*. APOE-sensitive cholinergic sprouting compensates hippocampal dysfunctions due to reduced entorhinal input. J Neurosci. 2016, 36(40):10472–10486 *: equal contributors.

Bott JB, Muller MA, Jackson J, Aubert J, Cassel JC, Mathis C, Goutagny R. (2015) Spatial Reference Memory is Associated with Modulation of Theta-Gamma Coupling in the Dentate Gyrus. Cereb Cortex. 2015 Aug 6. pii: bhv177.

Jackson J, Amilhon B, Goutagny R, Bott JB, Manseau F, Kortleven C, Bressler SL, Williams S. (2014) Reversal of theta rhythm flow through intact hippocampal circuits. Nat Neurosci ., 17(10):1362-70.

Goutagny R., Jackson J., Williams S. (2009) Self-generated theta oscillations in the hippocampus. Nat. Neurosci. , 12 (12) : 1491-3.

Grants

2012-2016: Marie Curie "Career Integration grant" fellowship

2013-2014: Neurex research grant

2012-2013: Fondation Fyssen research grant

2011-2012: NARSAD young investigator award

Technical Expertise

• Cortical oscillatory activity
• Hippocampo-cortical interactions during spatial memory processes
• Alteration of brain oscillatory activity in various model of neuropsychiatric disorders
• In vivo multi-site electrophysiological recording
• Behavioral testing