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Helmholtz Zentrum München
Institute of Developmental Genetics
Adult neurogenesis group
Ingoldstaedter Landstrasse 1, Neuherberg
D-85764 - Munich
Germany

+49 (0)89 3187 2927



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Dr Chichung D. Lie
Neuroimaging
Helmholtz Zentrum Munich

Research Area

The majority of neurons of the mammalian brain are generated during development and the early postnatal period.

During adulthood the generation of neurons from neural stem cells is restricted to the dentate gyrus of the hippocampal formation and the subventricular zone of the lateral ventricles. Our lab is interested in the molecular mechanisms that control adult hippocampal neurogenesis.

In particular, we are aim to characterize the signaling pathways that regulate the neuronal differentiation of neural stem cells and the integration of new hippocampal neurons into the adult neural network.

Moreover, we are interested in the question if and how these pathways are altered under pathological conditions and during aging.

To this end, we combine mouse models for neurodegenerative diseases, mouse genetics, and in vivo retro- and lentiviral manipulation, with cell culture models and biochemical analysis.

A better understanding of the regulatory mechanisms underlying neurogenesis in the adult mammalian brain may promote the development of novel therapeutic strategies which aim at the recruitment of endogenous neural stem cells for repair of the diseased central nervous system.


Publications

Jessberger S, Clark RE, Broadbent NJ, Clemenson GD Jr., Consiglio A, Lie DC, Squire LR, Gage FH (2008) Dentate gyrus-specific knockdown of adult neurogenesis identifies a role for newborn neurons in hippocampus-dependent learning and memory. PLoS Biology, accepted

Michaelidis TM, Lie DC (2008) Wnt signaling and neural stem cells: caught in the Wnt web. Invited Review in Cell Tissue Res Jan; 331(1):193-210.

Winner B, Rockenstein E, Lie DC, Aigner R, Mante M, Bogdahn U, Couillard-Despres S, Masliah E, Winkler J. (2008) Mutant alpha-synuclein exacerbates age-related decrease of neurogenesis. Neurobiol Aging. Jun;29(6):913-25. Epub 2007 Jan 31.

Jacobs S, Lie DC, DeCicco KL, Shi Y, DeLuca LM, Gage FH, Evans RM (2006) Retinoic acid is required early during adult neurogenesis in the dentate gyrus. Proc Natl Acad Sci U S A 103:3902-3907.

Jagasia R, Song H, Gage FH, Lie DC (2008) New regulators in adult neurogenesis and their potential role for repair. Trends Mol Med. 2006 Sep;12(9):400-5. Epub 2006 Aug 4.

Lie DC, Colamarino SA, Desire L, Song H, Mira H, Consiglio A, Lein ES, Jessberger S, Lansford H, Dearie A, Gage FH (2005) Wnt-signalling regulates adult hippocampal neurogenesis. Nature 437(7063):1370-5

Winner B, Lie DC, Rockenstein E, Aigner R, Aigner L, Masliah E, Kuhn HG, Winkler J. (2004) Human wild-type alpha-synuclein impairs neurogenesis. J Neuropathol Exp Neurol. Nov; 63(11):1155-66.

Shi YH, Lie DC, Taupin P, Nakashima K, Ray J, Yu RT, Gage FH, Evans RM (2004) Expression and function of orphan nuclear receptor TLX in adult neural stem cells. Nature 427: 78-83

Lie DC, Dziewczapolski G, Willhoite AR, Kaspar BK, Shults CW, Gage FH (2002) The adult substantia nigra contains progenitor cells with neurogenic potential. J Neurosci 22:6639-6649

Lie DC, Song H, Colamarino SA, Ming GL, Gage FH.(2004) Neurogenesis in the adult brain: new strategies for central nervous system diseases. Annu Rev Pharmacol Toxicol.;44:399-421. Review


More Publications

Bathellier, B., Buhl, D.L., Accolla, R. and Carleton. A.(2008):Dynamic ensemble odor coding in the mammalian olfactorybulb: sensory information at different time scales..Neuron:57: 586-598
Accolla, R., Bathellier, B., Petersen, C.C.H. and Carleton, A.(2007):DifferentiaI spatial representation oftaste modalities in the rat gustatory cortex..Journal of Neuroseience:27: 1396-1404
Bathellier, B., Van de Ville, D., Blu, T., Unser, M. and Carleton, A.(2007):Wavelet-basedmulti-resolution statistics foroptical imaging signaIs: application to automated detection of odour activated glomeruli in the mouse olfactory bulb..Neuroimage:34: 1020-1035
Carmena, A.*, Speicher, S. and Baylies M. (* corresponding author) (2006):"The PDZ protein Canoe/AF-6 Links Ras-MAPK, Notch and Wingless/Wnt Signaling Pathways by Directly Interacting with Ras, Notch and Dishevelled"..PLoS ONE 1(1):e66. doi:10.1371/journal.pone.0000066
P. Kievit, J. Howard, MM. Badman, N. Balthasar, R. Coppari, H. Mori, CE. Lee; JK. Elmquist, A. Joshimura, JS. Flier (2006):Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC neurons...Cell Metabolism:4(2):123-132.
Carmena, A. and Baylies, M.(2005):"The Development of the Drosophila Larval Somatic Musculature"..In “Drosophila Muscle Development”, H. Sink editor. Landes Bioscience.:
Stagi M., Dittrich P., Frank N., Iliev A., Schwille P and Neumann H.(2005):Breakdown of axonal synaptic vesicle precursor transport by microglial nitric oxide..J. Neurosci., 25(2):352-62
Iliev, A., Stringaris, A.K., Nau, R. and Neumann,H.(2004):Neuronal injury mediated via stimulation of microglial toll-like receptor-9 (TLR9)..FASEB J. 18, 412-414:1091-100
Carmena, A., Buff, E., Halfon, M.S., Gisselbrecht, S., Jiménez, F., Baylies, M.K., and Michelson, A.M.(2002):“Reciprocal regulatory interactions between the Notch and Ras signaling pathways in the Drosophila embryonic mesoderm"...Dev.Biol.:244, 226-242.
Halfon, M.S., Carmena, A., Gisselbrecht, S., Sackerson, C.M., Jiménez, F., Baylies, M.K. and. Michelson, A.M.(2000):“Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors”...Cell:103, 63-74

Technical Expertise