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Center for Neurogenomics and Cognitive Research
Biological Psychology
Van der Boechorststraat 1

1081 BT - Amsterdam
Netherlands

+31-(0)20-598 8814



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Dr Danielle Posthuma
Genetic Neusocience
Center for Neurogenomics and Cognitive Research (CNCR) Amsterdam

Research Area

The main goal of this project is to understand individual differences in human brain functioning, using an integrated molecular genetic approach.

This approach includes genomewide searches in humans for genetic areas that harbour genes for cognition, finemapping of these areas using single nucleotide polymorphisms (SNPs) and confirmation of these SNPs using brain expression analyses in humans and animals.

In addition, confirmation is sought using brain imaging techniques (fMRI) in humans. Several international groups serve as replication platforms for identified genetic variants for cognition. Ultimately we aim to identify gene-cascades involved in molecular mechanisms important for cognition.


Publications
Gosso M.F., de Geus E.J.C., van Belzen M.J., Pldermann T.J.C., Heutink P., Boomsma D.I., Posthuma D. (2006):The SNAP-25 gene is associated with cognitive abiiity: Evidence from a family based study in two independent Dutch cohorts..Mol Psychiat: 11(9):878-886
Posthuma D., de Geus E.J.C., Mulder E.J.C.M, Smit D.J.A., Boomsma D.I., Stam C.J. (2005):Genetic components of functional connectivity in the brain: the heritability of synchronization likelihood..Human Brain Mapping: 26, 191-198
Posthuma D., de Geus E.J.C., Baaré W.F.C., Hulshoff Pol H.E., Kahn R.S., Boomsma D.I. (2002):The association between brain volume and intelligence is of genetic origin..Nature Neuroscience: 5(2), 83-84
Hulshoff Pol H.E., Schnack H.G., Posthuma D., Mandl R.C.W., Baaré W.F., van Oel C., van Haren N.E:, Collins D.L., Evans A.C., Amunts K., Bürgel U., Zilles K., Geus E.J.C., Boomsma D.I., Kahn R.S. (.):A genetic neural network involved in human intelligence..Journal of Neurosience: 26(40):10235-42
Posthuma D., Luciano M., de Geus E.J.C., Wright M.J., Slagboom P.E., Montgomery G.W., Boomsma D.I., Martin N.G. (.):A genome-wide scan for intelligence identifies quantitative trait loci on 2q and 6p..Am J Hum Genet: 77(2),318-26

Technical Expertise