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The European Neuroscience Institute at University College London
LMP/Department for Pharmacology
Gower Street
WC1E 6BT - London
United Kingdom
+44 20 7679 7830
m.stocker@ucl.ac.uk
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Molecular and Cellular Neurobiology
The European Neuroscience Institute at University College London
Research Area
The group is studying:
- the molecular identity of potassium channels and their function in physiological contexts;
- the molecular and cellular mechanisms underlying ion channel targeting, clustering and regulation, and the constitution of protein complexes forming functional microdomains in native tissues, particularly in neurones.
The techniques we use are electrophysiology (neuronal cultures and brain slices), molecular biology, protein biochemistry and immunocyto/ histochemistry in combination with confocal microscopy.
Publications
Stocker M(2004):Ca(2+)-activated K+ channels: molecular determinants and function of the SK family..Nature Rev. Neurosci:758-770
D. D´hoedt, K. Hirzel, P. Pedarzani & M. Stocker (2004):Domain analysis of the calcium-activated potassium channel SK1 from rat brain: Functional expression and toxin sensitivity..J. Biol. Chem.:279: 12088-12092.
M. Stocker, K. Hirzel, D. D´hoedt & P. Pedarzani (2004):Matching molecules to function: Neuronal Ca2+-activated K+ channels and afterhyperpolari-zations..REVIEW:43: 933-949.
Kerschensteiner D., F. Monje and M. Stocker(2003):Structural determinants of the re gulation of the voltage-gated potassium channel Kv2.1 by the modulatory alpha-subunit Kv9.3..J. Biol. Chem:18154-18161
L.A. Cingolani, M. Gymnopoulos, A. Boccaccio, M. Stocker & P. Pedarzani (2002):Developmental regulation of small conductance Ca2+-activated K+ channel expression and function in rat Purkinje neurons..Journal of Neuroscience:22: 4456-4467.
P. Pedarzani, D. D´hoedt, K.B. Doorty, J.D.F. Wadsworth, J.S. Joseph, K. Jeyaseelan, R.M. Kini, S.V. Gadre, S.M. Sapatnekar, M. Stocker & P.N. Strong (2002):Tamapin, a venom peptide from the Indian red scorpion (Mesobuthus tamulus) that targets small conductance Ca2+-activated K+ channels and afterhyperpolarization currents in central neurons..J. Biol. Chem.:277: 46101-46109.
Technical Expertise