The major objective of our research is to understand the involvement of inflammation in neuronal injury as well as neuronal protection and regeneration. Furthermore, adult hematopoietic-derived stem and precursor cells will be applied as tool for cell and gene therapy of neuroinflammatory and neurodegenerative diseases.

more information: http://imbie.meb.uni-bonn.de/rnb/

Stagi M., Dittrich P., Frank N., Iliev A., Schwille P and Neumann H.(2005):Breakdown of axonal synaptic vesicle precursor transport by microglial nitric oxide..J. Neurosci., 25(2):352-62

Takahashi K., Rochford C.D. and Neumann H.(2005):Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2..J. Exp. Med., 201(4):647-57

Liu Y., Walter S., Stagi M., Cherny D., Letiembre M., Schulz-Schaeffer W., Heine H., Penke B., Neumann H. and Fassbender K.(2005):LPS receptor (CD14): a receptor for phagocytosis of Alzheimer’s amyloid peptide..Brain, 128(Pt 8):1778-89

Iliev, A., Stringaris, A.K., Nau, R. and Neumann,H.(2004):Neuronal injury mediated via stimulation of microglial toll-like receptor-9 (TLR9)..FASEB J. 18, 412-414:1091-100

Kempermann. G., Neumann, H.(2003):Microglia: The enemy within?..Science 302, 1689-1690 (Perspective):
Neumann H.(2003):Molecular mechanisms of axonal damage in inflammatory central nervous system diseases..Curr. Opin. Neurology, 16:267-273 (Review)

KempermaaNeumann H., Medana I., Bauer J., Lassmann H.nn. G., Neumann, H.(2002):Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases..Trends in Neurosci. 25 (6), 313-319 (Review):

Neumann,H., Schweigreiter,R., Yamashita,T., Rosenkranz,K., Wekerle,H. and Barde,Y.-A.(2002):Tumor necrosis factor inhibits neurite outgrowth and branching of hippocampal neurons by a Rho-dependent mechanism..Trends iJ. Neurosci. 22:854-862

Neumann,H.(2001):Control of glial immune function by neurons..Glia, 36:191-199 (Review)

Medana,I., Li,Z., Flügel,A., Tschopp,J., Wekerle,H., and Neumann,H.(2001):Fas Ligand (CD95L) protects neurons against perforin-mediated T lymphocyte cytotoxicity..J. Immunol. 167:674-681

Medana,I., Martinic, M.M.A., Wekerle,H. and Neumann,H.(2001):Transection of major histocompatibiltiy class I-induced neurites by cytotoxic T lymphocytes..Am. J. Pathol. 159:809-815